Parvovirus B19 viremia in children with systemic lupus erythematosus
نویسنده
چکیده
INTRODUCTION Human parvovirus B19 (PB19) is a single-stranded DNA virus that was first discovered in 1975 by Yvonne Cossart and her colleagues. It has been associated with a variety of clinical manifestations, including rash, thrombocytopenia, leukopenia, fetal wastage, hypocomplementemia, autoimmune hemolytic anemia, arthritis and vasculitis. It is the causative agent of erythema infectiosum (EI). In addition, B19 infection can be associated with elevated levels of antinuclear antibody, anti-double stranded DNA antibody, antineutrophil cytoplasmic antigens and anti-cardiolipin. Also, antiphospholipid antibodies, when seen in acute parvovirus B19 infection, may have the same specificity and cofactor dependence as antiphospholipid antibodies associated with systemic lupus erythematosus. B19 is a small, non-enveloped virus containing a single-stranded DNA of 5600 nucleotides and composed of two capsid proteins, VP1 (781 amino acids) and VP2 (554 amino acids), and a nonstructural protein, NS1. It targets early erythroid progenitor cells. It requires rapidly dividing cells in order to replicate. The cellular receptor is the P antigen (globoside, a glycosphingolipid), expressed in most individuals on mature erythrocytes and other cells. B19 infection is found worldwide in persons of all ages. Most people become infected at some time during their life, up to 15% of individuals developing infection between 1 and 5years of age, 15–60% between the ages of 5 and 19yeas, and 30–60% in adulthood. The detection of anti-VP1 and anti-VP2 antibodies is the basis for the diagnosis of acute or past B19 virus infections. The dominant humoral Original article
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Human parvovirus B19 infection in patients with systemic lupus erythematosus.
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تاریخ انتشار 2011